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. 2018 Nov 30;60(2):341–352. doi: 10.1194/jlr.M086215

Fig. 1.

Fig. 1.

Nonalcoholic steatohepatitis with insulin resistance induced by a HFD. A: The body weights of mice fed a HFD were significantly increased as compared with control mice after 3 months (males, n = 12, ***P < 0.001). B, C: AUC measurements of glucose tolerance and insulin sensitivity tests show an impaired insulin sensitivity in mice fed a HFD as compared with controls (P < 0.001). D: Phosphorylation of Akt (Ser473 and Thr308) was significantly decreased in livers from mice fed a HFD when compared with control mice (n = 3). E: HFD mice showed remarkable liver fat accumulation as observed by H&E staining (n = 3). F: Liver triglyceride and cholesterol levels were elevated in the HFD mice as compared with control mice (n = 12, *P < 0.05). G: There was no significant difference in the plasma triglyceride levels between HFD and control mice (P > 0.05). Total cholesterol (H), HDL (I), and LDL (J) levels were elevated in HFD mice as compared with controls (n = 12, ***P < 0.001).