Skip to main content
. 2018 Nov 30;60(2):242–268. doi: 10.1194/jlr.R089730

Fig. 8.

Fig. 8.

Class I START PITP function in apical loading of the Golgi system in neural stem cells. Class I START PITPs exchange PtdCho and PtdIns, thereby stimulating PI4K activity on late Golgi membranes. The PtdIns4P pool recruits GOLPH3 and CERT to Golgi membranes with GOLPH3 subsequently engaging the apically directed actin machinery via the nonconventional myosin, Myo18A. This interaction promotes loading of the Golgi system to the neural stem cell apical process, thereby setting up an asymmetry critical for neural establishment/maintenance of neural stem cell polarity.