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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: J Invest Dermatol. 2017 Dec 19;138(5):1187–1196. doi: 10.1016/j.jid.2017.11.038

Figure. 5. Diagram summarizing how miR-15b-5p orchestrates processes involved in pathophysiology of DFUs.

Figure. 5.

Persistent S. aureus colonization in DFUs leads to over-expression of miR-15b-5p resulting in increased DNA damage through suppression of WEE1 and chronic sub-optimal inflammation by targeting IKBKB. DNA repair mechanisms are further inhibited by down-regulation of multiple genes in DFUs including MSH2, RAD50, KIT, FGF2 and TP53. DNA damage feeds into a positive feedback loop by causing the release of IL-1A.