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We investigated the imaging data further by fitting linear regressions adjusting for age at death, total intracranial volume, and Braak stage. Our analysis showed that for cases with TDP-43 type-α had an estimated 11% (4%, 18%, p = 0.003) smaller amygdala volume than TDP-43 type-β. For hippocampi, TDP-43 type-α cases had 14% (7%, 22%, p <0.001) smaller volume than TDP-43 type-β cases. Plotted values are regression estimates and 95% confidence intervals.
