Table 3:
Clinical and Imaging characteristics
| TDP type-α (N = 131) | TDP type-β (N = 110) | P-value | |
|---|---|---|---|
| Last diagnosis, n (%) | 0.21 | ||
| Cognitively normal | 4 (3%) | 8 (8%) | |
| Mild cognitive impairment | 13 (11%) | 5 (5%) | |
| Alzheimer’s dementia | 92 (78%) | 76 (80%) | |
| Dementia NOS | 9 (8%) | 6 (6%) | |
| Clinical scores | |||
| MMSE | 16 (1,30) | 14 (0, 29) | 0.24 |
| CDRSUM | 12.0 (0.0, 18.0) | 13.0 (0.0, 18.0) | 0.63 |
| Boston Naming Score | 32 (1,58) | 32 (2, 60) | 0.76 |
| DRS total | 97 (23, 144) | 96 (28, 140) | 0.73 |
| AVLT Delayed Recall | 0 (0, 7) | 0 (0, 10) | 0.09 |
| WAIS-R Block Design | 8 (0,31) | 6 (0, 23) | 0.72 |
| WMSR LOG MEM II | 0 (0, 24) | 0 (0, 22) | 0.14 |
| Trail-Making-Test A | 85 (39, 180) | 74 (29, 180) | 0.17 |
| Trail-Making-Test B | 300 (96, 300) | 240 (57, 300) | 0.07 |
| COWAT | 20 (2, 54) | 17 (2,44) | 0.22 |
| Imaging | |||
| Amygdala | 1.8 (0.7,3.1) | 1.9 (1.2,3.0) | 0.14 |
| Hippocampus | 4.7 (1.6,8.1) | 5.2 (3.1,7.9) | 0.005 |
| Lateral temporal | 46.8 (27.9, 68.2) | 47.4 (32.8, 64.3) | 0.68 |
| Parietal | 38.9 (23.8, 52.6) | 37.1 (25.7, 52.2) | 0.01 |
| Superior frontal | 32.2 (21.5,46.4) | 31.8 (23.4,42.5) | 0.04 |
Data shown are median (range). P-values are from Wilcoxon Rank Sum tests. Clinical data are from the last available.
MMSE = Mini-Mental State Examination; CDRSUM = Clinical Dementia Rating Sum of Boxes; DRS = Dementia Rating Scale; AVLT = Auditory Verbal Learning Test; WAIS-R = Wechsler Adult Intelligence Scale revised version; WMS-R LOG MEM = Wechsler Memory Scale Revised Logical memory; COWAT = Control Oral word Association Test