TABLE 1.
Frequencies of the NOS3 gene G894T and -786T/C genotypes, alleles and haplotypes in Polish swimmers and controls.
| Group | n | NOS3 G894T genotypes | HWE | Glu298 allele, % | p | NOS3 -786T/C genotypes | HWE | T allele, % | p | NOS3 haplotypes | p§ | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GG (%) | GT (%) | TT (%) | p | TT (%) | TC (%) | CC (%) | p | G-T (%) | G-C (%) | T-C (%) | T-T (%) | |||||||||
| MALES | ||||||||||||||||||||
| Controls | 222 | 113 (50.9) | 89 (40.1) | 20 (9.0) | 1.000 | 0.744 | 71.0 | 1.000 | 92 (41.4) | 87 (39.2) | 43 (19.4) | 1.000 | 0.011* | 61.0 | 1.000 | 47.4 | 23.6 | 15.4 | 13.6 | 1.000 |
| SDS | 80 | 46 (57.5) | 27 (33.8) | 7 (8.7) | 0.575 | 0.376 | 74.4 | 0.408 0.469 |
38 (47.5) | 29 (36.3) | 13 (16.2) | 0.624 | 0.085 | 65.6 | 0.305 0.351 |
59.2 (0.036†) | 15.2 (0.087†) | 19.2 (0.596†) | 6.4 (0.042†) | 0.005 |
| LDS | 24 | 14 (58.3) | 9 (37.5) | 1 (4.2) | 0.649 | 1.000 | 77.1 | 0.371 0.467 |
12 (50.0) | 11 (45.8) | 1 (4.2) | 0.181 | 0.636 | 72.9 | 0.107 0.145 |
59.3 (0.110†) | 17.7 (0.347†) | 9.3 (0.232†) | 13.6 (0.990†) | 0.453 |
| FEMALES | ||||||||||||||||||||
| Controls | 157 | 104 (66.2) | 48 (30.6) | 5 (3.2) | 1.000 | 1.000 | 81.5 | 1.000 | 63 (40.1) | 81 (51.6) | 13 (8.3) | 1.000 | 0.077 | 65.9 | 1.000 | 58.7 | 22.8 | 11.3 | 7.2 | 1.000 |
| SDS | 67 | 30 (44.8) | 28 (41.8) | 9 (13.4) | 0.001 | 0.590 | 65.7 | 0.00027 0.00043 |
25 (37.3) | 30 (44.8) | 12 (17.9) | 0.109 | 0.613 | 59.7 | 0.209 0.250 |
48.3 (0.025†) | 17.4 (0.198†) | 22.9 (0.001†) | 11.4 (0.062†) | 0.005 |
| LDS | 26 | 17 (65.4) | 7 (26.9) | 2 (7.7) | 0,526 | 0.288 | 78.9 | 0.647 0.790 |
16 (61.5) | 10 (38.5) | 0 (0.0) | 0.071 | 0.545 | 80.8 | 0.033 0.049 |
67.6 (0.195†) | 11.3 (0.035†) | 7.9 (0.427†) | 13.2 (0.112†) | 0.079 |
| TOTAL | ||||||||||||||||||||
| Controls | 379 | 217 (57.3) | 137 (36.1) | 25 (6.6) | 1.000 | 0.582 | 75.3 | 1.000 | 155 (40.9) | 168 (44.3) | 56 (14.8) | 1.000 | 0.377 | 63.1 | 1.000 | 52.0 | 23.3 | 13.6 | 11.1 | 1.000 |
| SDS | 147 | 76 (51.7) | 55 (37.4) | 16 (10.9) | 0.209 | 0.235 | 70.4 | 0.103 0.120 |
63 (42.9) | 59 (40.1) | 25 (17.0) | 0.647 | 0.111 | 62.9 | 0.964 0.975 |
54.3 (0.811†) | 16.1 (0.032†) | 21.0 (0.015*†) | 8.6 (0.602†) | 0.007 |
| LDS | 50 | 31 (62.0) | 16 (32.0) | 3 (6.0) | 0.815 | 0.680 | 78.0 | 0.559 0.645 |
28 (56.0) | 21 (42.0) | 1 (2.0) | 0.020* | 0.419 | 77.0 | 0.0061 0.0085 |
63.7 (0.025†) | 14.3 (0.032†) | 8.7 (0.129†) | 13.3 (0.418†) | 0.064 |
p values were calculated by χ2 test and χ2 test with Yates’ correction for comparisons between groups of athletes and control group HWE – χ2 test for Hardy-Weinberg equilibrium,
§
global score statistic, additive haplotype effect, † versus Controls.