Table 1.

Properties of PFK2 isoenzymes.

Gene	Tissue expression pattern	Kinase/bisphosphatase ratio	Expression in cancers
PFKFB1	Liver, muscle, white adipose tissue, fetal, hypoxia inducible	2.5 (rat liver) 1.2 (bovine liver) 0.4 (rat muscle)	Not detected
PFKFB2	Heart, hypoxia inducible	1.8 (bovine heart)	Melanoma [133], osteosarcoma [134], HCC [135], prostate cancer [136]
PFKFB3	Ubiquitous, hypoxia inducible	710:1 (human placenta)	Breast cancer, colon cancer, HCC, astrocytoma, glioma
PFKFB4	Testis, hypoxia inducible	4.6:1 (recombinant human PFKFB4), 0.9 (human testis)	SCNC, glioblastoma, bladder cancer, gastric, pancreatic cancer, prostate cancer, AML