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. 2018 Dec 2;20:89–101. doi: 10.1016/j.molmet.2018.11.011

Figure 3.

Figure 3

CX3CL1-Fc administration reduces atherosclerosis after diet switch. (A) A schematic of the diet switch study. CX3CL1-Fc injections began after switch from 4 months of WD to normal chow diet (NCD). (B) Body weight of baseline mice are significantly higher than 8 month mice after diet switch (n = 8–10). (C–F) Serum lipid analyses. Total serum cholesterol (C) and triglycerides (D) are significantly decreased in mice that are switched from WD to NCD with no differences between CX3CL1-Fc-treated mice and controls (n = 6–9). FPLC profiles of cholesterol (E) and triglycerides (F) show a decrease in 4 and 8 month diet switch mice with no difference between CX3CL1-Fc and VEH controls (Data are a pool of serum from 8 mice). (G) En face analysis of total aorta. Aortic lesion area is reduced in CX3CL1-Fc-treated mice compared to controls at 4 and 8 months after diet switch. Representative images are shown on the right (n = 7–10). (H) Cross-sectional analysis of aortic root area. Aortic root sections shown as area under the curve have significantly less lesion area in CX3CL1-Fc mice at 4 and 8 months after diet switch (n = 7–12). AUC, area under the curve. A.U., arbitrary unit. In all panels, data are presented as mean ± SD. */& p < 0.05, **/&& p < 0.01, ***/&&& p < 0.001. In (H), * denotes significance between 4M VEH and 4M CX3CL1-Fc, while & denotes significance between 8M VEH and 8M CX3CL1-Fc.