Fig. 2.

Dapagliflozin-induced increases in hepatic ketogenesis and hepatic glucose production are caused by extracellular volume depletion. a Weight change from baseline (time of injection) measured six hours after treatment. b–d Plasma epinephrine, corticosterone, and glucagon concentrations. Data are the mean ± S.E.M., with comparisons by ANOVA with Bonferroni’s multiple comparisons test. e, f Weight change and plasma glucose concentrations six hours after treatment with furosemide. g Plasma epinephrine. h Whole-body β-OHB turnover. In panels e–h, comparisons were performed using the 2-tailed unpaired Student’s t-test. Data are the mean ± S.E.M