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. 2019 Jan 11;116(5):1686–1691. doi: 10.1073/pnas.1812155116

Fig. 2.

Fig. 2.

Brain uptake of CSF1R radiotracer [11C]CPPC in control (Ctrl), LPS (i.p.)-treated mice (LPS base), and LPS (i.p.)-treated mice plus blocking with CSF1R inhibitors (LPS block) in three independent experiments. The time point was 45 min after radiotracer injection [LPS (10 mg/kg)]. (A) Data are mean %SUV ± SD (n = 5). CB, cerebellum. (B) Data are mean SUVR ± SD (n = 5). Blocker (CPPC, 1 mg/kg, i.p.) was injected in the LPS-treated mice. (C) Data are mean SUVR ± SD (n = 3–6). Blocker (compound 8, 2 mg/kg, i.p.) was injected in the LPS-treated mice. Statistical analysis: comparison of LPS-baseline versus control or LPS-block. *P < 0.01; **P = 0.03; no asterisk indicates P > 0.05 (ANOVA).