PET imaging of [11C]CPPC in the same baboon in baseline, LPS, and LPS-plus-blocking experiments. The LPS dose was 0.05 mg/kg (i.v.), 4 h before radiotracer injection. (A) Parametric (VT) images. (B) Baseline regional brain SUV time-uptake curves of [11C]CPPC. (C) Whole-brain SUV time-uptake curves of [11C]CPPC: baseline (green), after LPS treatment (red) and blocking after LPS treatment (black). (D) Metabolite-corrected plasma SUV time-uptake curves of [11C]CPPC: baseline (green), after LPS treatment (red), and LPS-plus-blocking (black). The Inset in D shows first 120 s of scanning.