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. 2019 Jan 11;116(5):1704–1713. doi: 10.1073/pnas.1804858116

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Fig. 6. — Sox9 overexpression permits spheroid development in Arid1a mutant mice. (A) Time-course images of spheroids generated from crypts in control (Left), Villin-Cre; Arid1a^f/f (Center), and Villin-Cre; Arid1a^f/f; SOX9OE intestines (Right) at 8 wk of age. (Scale bars, 100 µm.) (B) The number of spheroids generated from 100 crypts in control (n = 4), Villin-Cre;Arid1a^f/f (n = 30), and Villin-Cre;Arid1a^f/f;SOX9OE intestines (n = 4) at day 4. (C) Diameter of spheroids at indicated time points, generated from crypts in control (n = 24), Villin-Cre;Arid1a^f/f (n = 37), and Villin-Cre;Arid1a^f/f; SOX9OE intestines (n = 38). Quantitative data are presented as means ± SD, **P < 0.01, ***P < 0.001.