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LPL and GPIHBP1 itinerary and function. LPL is synthesized by parenchymal cells as dimers that are secreted into the subendothelial space where one GPIHBP1 molecule on the surface of the endothelial cell binds one molecule of LPL. The LPL–GPIHBP1 complex is then moved across the cell in vesicles to the capillary lumen. GPIHBP1 anchors LPL to the endothelial cell and is required for margination of chylomicrons and VLDL particles, which permits the hydrolysis of triglycerides by LPL.
