(B)
| Study Authors and Years of Publications | Locations of the Studies | Patients with AD Sites of Recruitment | Case Definitions | AD Serum BDNF Mean (SD) | Numbers of Patients with AD; Ratio Male/Female | Average Age | Individuals with MCI Sites of Recruitment | Case Definitions | MCI Serum BDNF Mean (SD) | Numbers of Individuals with MCI; Ratio Male/Female | Average Age | Total Numbers of Subjects; Ratio Male/Female |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Alvarez et al. (2014) [12] | A Coruña, Granada and Málaga, Spain | Three institutions specialized in cognitive disorders | DSM-IV and NINCDS-ADRDA criteria | 15.16 (9.48) | 252; M = 56, F = 196 | 74.99 (7.35) | Subjects evaluated at three institutions specialized in cognitive disorders | Petersen criteria revised | 14.33 (9.12) | 48; M = 13 F = 35 |
73.46 (7.57) |
300; M = 69, F = 231 |
| Angelucci et al. (2010) [3] | Rome, Italy | NA | NINCDS-ADRDA and MMSE | 6.07 (1.38) | 89 Mild AD: 54; M = 19, F = 35 Moderate-severe AD: 35; M = 8, F = 22 |
Mild AD (n = 54) 74.31 (6.97) Moderate-severe AD (n = 35) 77.42 (8.27) |
NA | Peterson’s guidelines and MMSE score ≥23 | 6.20 (1.50) | 54; M = 32, F = 27 |
69.61 (6.65) |
143; M = 59, F = 84 |
| Forlenza et al. (2015) [13] | São Paulo, Brazil | Community-dwelling elders recruited from an ongoing cohort study | NINCDS-ADRDA criteria | 0.66 (0.49) | 26; M = 8, F = 18 | 76.8 (6.6) |
Community-dwelling elders recruited from an ongoing cohort study | Mayo Clinic criteria | 0.51 (0.27) | 62; M = 17, F = 45 | 72.2 (6.2) |
88; M = 25, F = 63 |
| Gezen-ak et al. (2013) [29] | Istanbul, Turkey | Behavioral Neurology and Movement Disorder Clinic | DSM-VI and MMSE | 0.93 (0.31) | 76; NA; EOAD = 22, LOAD = 54 | EOAD = 61.1 (4.8); LOAD = 74.22 (3.73) | Behavioral Neurology and Movement Disorder Clinic | NA | 1.15 (0.40) |
30; NA | 74.4 (2.9) |
101; NA |
| Laske et al. (2006C) [15] | Tübingen, Germany | NA | MMSE <26 + > or =21 | 19.60 (4.50) | 30; NA | NA | NA | MMSE ≥26 | 24.10 (5.40) | 12; NA | NA | 42; NA |
| Lee et al. (2009) [16] | Busan, South Korea | Patients of the Busan Paik Hospital | MMSE-KC, CERAD-K, CDRS, DSM-IV, NINCDS-ADRDA criteria | 22.90 (5.00) | 47; NA | NA | Patients of the Busan Paik Hospital | CDRS and Peterson’s Criteria | 22.80 (6.30) |
41; NA | NA | 88; NA |
| Lee et al. (2015) [17] | Busan, South Korea | Elderly individuals over 60 years of age | MMSE-KC, CERAD-K, CDRS, DSM-IV | 29.10 (7.70) | 25; NA | 73.3 (6.8) |
Elderly individuals over 60 years of age | MMSE-KC, CERAD-K, CDRS, DSM-IV | 28.70 (7.00) | 55; NA | 71.5 (4.7) |
80; NA |
| Woolley et al. (2012) [11] | California, USA | Memory and Aging Center | NINCDS-ADRDA criteria | 23.00 (11.00) | 34; M = 18, F = 16 | 66.1 (11.3) | Memory and Aging Center | Peterson’s Criteria | 17.00 (12.00) | 30; M = 17, F = 13 | 71.3 (11.5) |
64; M = 35, F = 29 |