(C)
| Study Authors and Years of Publications | Locations of the Studies | Individuals with Mci Sites of Recruitment | Case Definitions | MCI Serum BDNF Mean (SD) | Numbers of Individuals with MCI; Ratio Male/Female | Average Age | Healthy Controls Sites of Recruitment | Methods of Cognitive Assessments | Control Serum BDNF Mean (SD) | Numbers of Healthy Controls; Ratio Male/Female | Average Age | Total Numbers of Subjects; Ratio Male/Female |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Alvarez et al. (2014) [12] | A Coruña, Granada and Málaga, Spain | Three institutions specialized in cognitive disorders | Petersen’s criteria revised | 14.33 (9.12) |
48; M = 13, F = 35 |
73.46 (7.57) | Subjects evaluated at three institutions specialized in cognitive disorders | MMSE and ADAS-cog+ | 16.73 (11.83) | 38; M = 8, F = 30 |
72.74 (5.69) | 86; M = 21, F = 65 |
| Angelucci et al. (2010) [3] | Rome, Italy | NA | Peterson’s guidelines and MMSE score = or > 23 | 6.20 (1.50) | 54; M = 32, F = 22 |
69.61 (6.65) | NA | MMSE score >24 and not satisfying the NINCDS-ADRDA criteria nor the Petersen’s criteria, confirmed by the memory tests of the MBD |
5.17 (1.39) | 27; M = 10, F = 17 |
68.48 (6.12) | 81; M = 42, F = 39 |
| Forlenza et al. (2015) [13] | São Paulo, Brazil | Community-dwelling elders recruited from an ongoing cohort study | Mayo Clinic criteria | 0.51 (0.27) | 62; M = 17, F = 45 |
72.2 (6.2) |
Community-dwelling elders recruited from an ongoing cohort study | Cambridge Cognitive Test, MMSE, and neuropsychological tests | 0.84 (0.69) | 46; M = 9, F = 37 |
68.8(6.8) | 108; M = 26, F = 82 |
| Gezen-ak et al. (2013) [29] | Istanbul, Turkey | Behavioral Neurology and Movement Disorder Clinic | DSM-VI and MMSE | 1.15 (0.40) | 29; NA | 74.4 (2.9) |
Behavioral Neurology and Movement Disorder Clinic | NA | 1.25 (0.48) | 29; NA | 72.1 (3.4) |
58; NA |
| Laske et al. (2006C) [15] | Tübingen, Germany | NA | MMSE > or = 26 | 24.10 (5.40) | 12; NA | NA | NA | NA | 21.10 (4.70) | 20; NA | NA | 32; NA |
| Lee et al. (2009) [16] | Busan, South Korea | Patients of the Busan Paik Hospital | CDRS and Peterson’s Criteria | 22.80 (6.30) | 41; M = 17, F = 24 |
74.1 (5.7) |
Patients of the Busan Paik Hospital | MMSE-KC scores >25 | 27.90 (6.90) | 39; M = 16, F = 23 |
72.8 (5.0) |
80; M = 33, F = 47 |
| Lee et al. (2015) [17] | Busan, South Korea | Elderly individuals over 60 years of age | MMSE-KC, CERAD-K, CDRS, DSM-IV | 28.70 (7.00) | 55; NA | 71.5 (4.7) |
Elderly individuals over 60 years of age | Score >1.5 standard deviations (SD) above the mean MMSE-KC score | 26.80 (5.30) | 59; NA | 72.0 (5.8) |
114; NA |
| Shimada et al. (2014) [18] | Obu, Japan | Subjects enrolled in the OSHPE | ≤23 points on the MMSE and NCGG-FAT (for screening), Petersen’s Criteria for diagnosis | 20.90 (5.30) | 827; NA | NA | Enrolled in the OSHPE | NA | 21.20 (5.40) | 3636; NA | NA | 4463; NA |
| Woolley et al. (2012) [11] | California, USA | Memory and Aging Center | Peterson’s Criteria | 17.00 (12.00) | 30; M = 17, F = 13 | 71.3 (11.5) |
Recruited through advertisements in local newspapers and recruitment talks at local senior community centers. | A normal result from neurological examination, a CDR score of 0, and MMSE score ≥28/30. | 19.00 (11.00) | 38; M = 15, F = 23 | 69.2 (9.8) |
68; M = 32, F = 36 |
Abbreviations: DSM-V: The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition; ICD-10: 10th revision of the International Statistical Classification of Diseases and Related Health Problems; NINCDS-ADRDA: National Institute of Neurological and Communicative Disorders and Stroke (NINCDS) and the Alzheimer’s Disease and Related Disorders Association (ADRDA) criteria; MMSE: Mini-Mental State Examination, ADAS-cog+: The Alzheimer’s Disease Assessment Scale Cognitive Plus; MMSE-KC: Mini-Mental Status Examination: Korean version; CERAD-K: Consortium to Establish a Registry for Alzheimer’s Disease, Korean version; CDR: Clinical Dementia Rating; CDRS: Clinical Dementia Rating Scale; EEG: electroencephalogram; CT: computerized tomography; MRI: magnetic resonance imaging; MDB: Mental Deterioration Battery; TARC: Texas Alzheimer’s Research Consortium; FAST: Functional Assessment Staging; OSHPE: Obu study of health promotion for the elderly; NCGG-FAT: the National Center For Geriatrics And Gerontology-Functional Assessment Tool; USA: United States of America; MBD: Mental Deterioration Battery; NA represents data not reported in the respective studies.