Table 3.

Overview of polymer-free CyD/drug ICs electrospun nanofibers used in drug delivery.

CyD type	Active molecule	Release data	Ref
HP-β-CyD, HP-γ-CyD	Triclosan	Rapid release on contact with water and significant inhibition against E. coli and S. aureus	[165]
HP-β-CyD, HP-γ-CyD	Camphor	In gas phase, faster release at higher temp., faster for the HP-β-CyD system	[166]
HP-β-CyD, HP-γ-CyD, and M-β-CyD	Eugenol	Rapid release on contact with water, enhanced antioxidant activity than eugenol itself	[167]
HP-β-CyD, HP-γ-CyD	Cineole and p-cymene	Rapid release along with the fiber dissolution	[168]
HP-β-CyD, HP-γ-CyD, and M-β-CyD	Linalool	Rapid release, significant inhibition against the growth of E. coli and S. aureus	[169]
HP-β-CyD, HP-γ-CyD and M-β-CyD	Limonene	25% Release M-β-CyD/limonene-IC-NF, 51% release HP-β-CyD/limonene-IC-NF, 88% release HP-γ-CyD/limonene-IC-NF in 100 days	[170]
HP-β-CyD, HP-γ-CyD and M-β-CyD	Geraniol	Long-term stability of geraniol in gas phase	[171]
HP-β-CyD, HP-γ-CyD and M-β-CyD	Thymol	Immediately on contact with water	[172]
HP-β-CyD, HP-γ-CyD	Menthol	Rapid release along with the fiber dissolution	[173]
HP-β-CyD, HP-γ-CyD and M-β-CyD	Vanillin	Immediately on contact with water, enhanced antioxidant activity with nanofibers	[174]
HP-β-CyD	Vitamin E	Rapid and enhanced release, higher antioxidant activity with CyD	[175]
HP-β-CyD, HP-β-CyD	Carvacrol	Rapid release on contact with water	[176]
SBE7-β-CyD	Sulfisoxazole	Rapid and enhanced release of sulfisoxazole on contact with water	[179]
HP-β-CyD	Diclofenac sodium	Release in few minutes	[180]
HP-β-CyD	Spironolactone	Total release in 1 h	[181]
Phenylacetic-β-CyD	Doxorubicin, fluorescein isothiocyanate-dextran (FITC-dextran), recombinant human insulin (FITC-labeled insulin) and chlorin e6	50% Release of drugs in vitro in 30 days, ~100% release of chlorin in vivo on day 28	[182]