Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jan 21;20(2):453. doi: 10.3390/ijms20020453

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Schematics of different strategies for remodelling AML in mice. (A) Spontaneous AML development upon exposure to carcinogens like chemicals (e.g., 3-methylcholantrene; 3M-C), biologicals (e.g., murine leukaemia virus, MuLV) or radiation (X-rays). (B) Conventional transgenic approach: Transgenic (Tg) mouse lines are generated by DNA insertion into the genome, either randomly by pronuclear microinjections (MI) into fertilized Oocytes, or targeted by electroporation (EP) and homologous recombination in embryonic stem cells (ESC). (C) Adaptive transfer method of in vitro modified murine HSPC cells using either retroviral transduction (RV) or genome editing (GE) techniques followed by tail intravenous (IV) transplantation in irradiated (IR) recipients. (D) Xenotransplantation of either leukemic blasts or in vitro modified HSPC into immuno-compromised mice intravenously (IV) injected into irradiated (IR) recipients.