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. 2019 Jan 16;20(2):347. doi: 10.3390/ijms20020347

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Expression of chromatin modifying genes in HepG2 cells before and after stimulation with Vitamin C alone or in combination with 5-Azacytidine (5-AZA) was measured by using the Chromatin Modification Array. Genes responsible for the maintenance of metabolic properties of primary human hepatocytes (PHH) are selected. (a) Expression of chromatin modification genes in HepG2 compared to PHH (b) Changes in the expression of chromatin modification genes in HepG2 caused by treatment with Vitamin C compared to non- stimulated HepG2 cells. (c) Changes in the expression of chromatin modification genes in HepG2 caused by 5-AZA in combination with Vitamin C compared to non- stimulated HepG2 cells.