Table 1.
Proteins identified in the exosomes of NCI-H838 cells which were reported as potential biomarkers for lung cancer.
| Protein Accessions | Protein Descriptions | Ratio of Mass Spectrometry Signal Intensity in Exosomal to Membrane Proteins | References |
|---|---|---|---|
| P48509 | CD151 antigen (CD151) | 27.092 | [23] |
| P07996 | Thrombospondin-1 (THBS1) | 259.860 | [24,25,26,27] |
| P06744 | Glucose-6-phosphate isomerase (GPI) | 10.700 | [24] |
| P37837 | Transaldolase (TALDO1) | 8.424 | [24] |
| Q5NKV8 | Intercellular adhesion molecule 1 (ICAM1) | 6.001 | [24] |
| Q5U077 | L-lactate dehydrogenase (LDHB) | 3.307 | [24] |
| Q60FE6 | Filamin A (FLNA) | 0.900 | [24] |
| P12814 | Alpha-actinin-1 (ACTN1) | 0.251 | [24] |
| P11413 | Glucose-6-phosphate 1-dehydrogenase (G6PD) | 5.411 | [24] |
| Q14766 | Latent-transforming growth factor beta-binding protein 1 (LTBP1) | 2.894 | [25] |
| Q59EN5 | Prosaposin variant (PSAP) | 0.176 | [25] |
| Q01081 | Splicing factor U2AF 35 kDa subunit (U2AF1) | 0.182 | [25] |
| Q5HYB6 | Epididymis luminal protein 189 (TPM3) | 0.838 | [26] |
| Q7Z6Z7 | E3 ubiquitin-protein ligase HUWE1 (HUWE1) | 1.730 | [26] |
| P10124 | Serglycin (SRGN) | 18.260 | [26] |
| P14174 | Macrophage migration inhibitory factor (MIF) | 9.645 | [27] |
| X5DNK3 | Receptor protein-tyrosine kinase (Fragment) (ERBB2) | 0.179 | [27] |
| P62805 | Histone H4 (HIST1H4A) | 186.179 | [28] |
| P39060 | Collagen alpha-1(XVIII) chain (COL18A1) | 133.480 | [28] |
| P08133 | Annexin A6 (ANXA6) | 242.502 | [28] |
| P68366 | Tubulin alpha-4A chain (TUBA4A) | 13.347 | [28] |
| P59998 | Actin-related protein 2/3 complex subunit 4 (ARPC4) | 2.852 | [28] |
| Q15084 | Protein disulfide-isomerase A6 (PDIA6) | 0.016 | [28] |
| P07237 | Protein disulfide-isomerase (P4HB) | 0.011 | [28] |
| Q6FGX5 | TIMP metallopeptidase inhibitor 1, isoform CRA_a (TIMP1) | 2.671 | [29] |
| P21741 | Midkine (MDK) | 34.132 | [29] |
| P06733 | Alpha-enolase (ENO1) | 16.102 | [24,30] |
| P08195 | 4F2 cell-surface antigen heavy chain (SLC3A2) | 10.947 | [31] |
| P05556 | Integrin beta-1 (ITGB1) | 3.037 | [31] |
| P13473 | Lysosome-associated membrane glycoprotein 2 (LAMP2) | 2.789 | [31] |
| Q01650 | Large neutral amino acids transporter small subunit 1 (SLC7A5) | 8.272 | [32] |
| P15941 | Mucin-1 (MUC1) | 8.977 | [32,33,34] |
| P07900 | Heat shock protein HSP 90-alpha (HSP90AA1) | 5.526 | [35] |
| P07947 | Tyrosine-protein kinase Yes (YES1) | 4.321 | [35] |
| P41743 | Protein kinase C iota type (PRKCI) | 1.545 | [35] |
| Q07954 | Prolow-density lipoprotein receptor-related protein 1 (LRP1) | 5.011 | [36] |
| V9HWN7 | Fructose-bisphosphate aldolase (ALDOA) | 3.090 | [24,36] |
| Q06830 | Peroxiredoxin-1 (PRDX1) | 2.424 | [36] |
| Q5TZZ9 | Annexin (ANXA1) | 2.113 | [37] |
| P13010 | X-ray repair cross-complementing protein 5 (XRCC5) | 1.456 | [38] |
| P06748 | Nucleophosmin (NPM1) | 0.063 | [39] |
| Q13011 | Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) | 0.031 | [40] |