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Effect of ciprofloxacin on the efflux of the substrates of ABCB1. A time course (0, 30, 60, 120 min) versus the percentage of intracellular [3H]-paclitaxel remaining (%) was plotted to show the effect of ciprofloxacin in SW620 (A), SW620/AD300 (B), HEK293/pcDNA3.1 (C), and HEK293/ABCB1 (D) cells. Error bars represent the SD, *p < 0.05 versus the control group. Verapamil 10 μM is used as positive control for ABCB1-overexpressing cells.
