Table 2.
Echocardiography data of Apelin KO mice treated with an ACE inhibitor. Values are mean ± SEM. See Table 1 for abbreviations. The ACE inhibitor (ACE-i) Captopril was given in drinking water for 2 weeks before echocardiography. * p < 0.05 and ** p < 0.01 compared with control wild type mice. # p < 0.05 compared to vehicle treated Apelin KO mice.
| Wild Type + Vehicle | Apelin KO + Vehicle | Wild Type + ACE-i | Apelin KO + ACE-i | |
|---|---|---|---|---|
| N | 5 | 5 | 6 | 5 |
| age (M) | 12 | 12 | 12 | 12 |
| HR (bpm) | 476.20 ± 18.00 | 464.40 ± 11.50 | 480.60 ± 11.90 | 455.00 ± 15.90 |
| FS (%) | 39.60 ± 0.81 | 29.60 ± 1.08 ** | 40.40 ± 1.29 | 39.25 ± 0.06 |
| LVESD (mm) | 2.26 ± 0.04 | 2.76 ± 0.02 * | 2.16 ± 0.04 | 2.33 ± 0.02 # |
| LVEDD (mm) | 3.74 ± 0.05 | 3.90 ± 0.05 * | 3.76 ± 0.06 | 3.85 ± 0.06 |
| PWT (mm) | 0.88 ± 0.02 | 0.72 ± 0.02 ** | 0.86 ± 0.02 | 0.83 ± 0.04 # |