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. 2019 Jan 12;20(2):294. doi: 10.3390/ijms20020294

Figure 6.

Figure 6

Effect of ER-β silencing, ritonavir (RTV), and ginsenoside Rb1 on the mRNA levels of eNOS in HUVECs (real time PCR). (A) eNOS mRNA levels in HUVECs treated with control siRNA. RTV treatment decreased eNOS mRNA levels, and ginsenoside Rb1 effectively blocked this effect of RTV in HUVECs with control siRNA; (B) eNOS mRNA levels in HUVECs treated with ER-β siRNA. RTV treatment decreased eNOS mRNA levels, while Rb1 did not block RTV-induced reduction of eNOS mRNA levels in HUVECs with ER-β silencing. Student’s t-test was used to compare the control with the treated groups or between two groups. * p < 0.05. n = 3/group. eNOS (endothelial nitric oxide synthase); HUVECs (human umbilical vein endothelial cells); siRNA (small interfering RNA); PCR (polymerase chain reaction).