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. 2019 Jan 11;20(2):270. doi: 10.3390/ijms20020270

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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ΔNp63α is essential for the expression of epidermal growth factor receptor (EGFR) and phosphatase 1D (Wip1). (A) Representative Western blot of EGFR expression and its activated form pEGFR (phosphorylated at Tyr1068) in parental MCF-7cells and in non-silenced and shRNAp63α-silenced 6D cells. (B) Wortmannin’s inhibitory effect on ΔNp63α and EGFR overexpression and phosphorylation of the latter. (C) Western blot analysis of ataxia-telangiectasia mutated (ATM) and Wip1 expression in the cells indicated in panel A. Densitometric analyses of Western blots show the results of at least three independent experiments.