Figure 2.

Prevailing topology of the full length human LETM1 monomer. The topology is shown with respect to the inner-mitochondrial membrane (IMM) showing the N-terminal region within the mitochondrial inter-membrane space (IMS) and the C-terminal region within the mitochondrial matrix. The locations of the coiled-coils (CCn; red) relative to the transmembrane domain (TM; green), the EF-hand motif (yellow) and the IMS and matrix compartments are shown. The Ca²⁺ cation coordinated by the EF-hand loop is indicated by the arrow. The amino and carboxyl termini are denoted by N and C, respectively.