Table 2.
Cytotoxic activity of vanadium complexes on PANC-1, MIA PaCa2 and hTERT-HPNE cell lines after 48 h of treatment. Data are expressed as IC50 and logIC50 (mean ± SD of 3 separate determinations) and were calculated on the basis of MTT and NR determinations.
| MTT Assay | ||||||
| PANC-1 | MIA PaCa2 | hTERT-HPNE | ||||
|
IC50
[μM] |
LogIC50± SD
[μM] |
IC50
[μM] |
logIC50 ± SD
[μM] |
IC50
[μM] |
logIC50 ± SD
[μM] |
|
| T1 | 44.67 | 1.650 ± 0.042 | 72.22 | 1.859 ± 0.022 | 140.9 | 2.149 ± 0.036 |
| T2 | 45.53 | 1.658 ± 0.040 | 77.29 | 1.888 ± 0.026 | 138.9 | 2.143 ± 0.029 |
| T3 | 61.45 | 1.788 ± 0.039 | 76.05 | 1.881 ± 0.025 | 116.8 | 2.067 ± 0.018 |
| C7 | 45.94 | 1.662 ± 0.030 | 63.82 | 1.805 ± 0.025 | 121.8 | 2.086 ± 0.034 |
| NR Assay | ||||||
| PANC-1 | MIA PaCa2 | hTERT-HPNE 1 | ||||
|
IC50
[μM] |
logIC50± SD
[μM] |
IC50
[μM] |
logIC50 ± SD
[μM] |
IC50
[μM] |
logIC50 ± SD
[μM] |
|
| T1 | 59.73 | 1.776 ± 0.066 | 39.46 | 1.596 ± 0.030 | >200 | - |
| T2 | 43.65 | 1.640 ± 0.049 | 37.92 | 1.579 ± 0.029 | >200 | - |
| T3 | 123.4 | 2.091 ± 0.063 | 32.07 | 1.506 ± 0.033 | >200 | - |
| C7 | 99.72 | 1.999 ± 0.075 | 33.12 | 1.520 ± 0.023 | >200 | - |
1 Cell viability decrease was too low to calculate IC50; The underlined complex was exhibited the most favorable cytotoxic profile.