Table 3.

PK parameters of PTX orally co-administrated with compound 4 (2 and 5 mg/kg, PO) in rats.

PK Parameters	PTX Oral Control	Co-Administration of PTX with Compound 4		PTX IV Control
		2 mg/kg	5 mg/kg
Cmax (ng/mL)	189 ± 76	112 ± 55	175 ± 0.032	2968 ± 428
Tmax (h)	2.0	[2.0–8.0]	3.0
AUCinf (ng·h/mL)	745 ± 208	1162 ± 322	1539 ± 209 *	835 ± 155
t1/2 (h)	3.1 ± 0.8	7.9 ± 2.0 *	11.0 ± 2.7 *	2.06 ± 0.8
ke (1/h)	0.233 ± 0.062	0.092 ± 0.027 *	0.066 ± 0.016 *	0.37 ± 0.12
Vz/F (mL)	40,589 ± 16,353	56,582 ± 25,172	53,466 ± 15,335	1754 ± 419
Cl/F (mL/h)	8721 ± 2040	4811 ± 1406 *	3356 ± 455 *	614 ± 123
AB (%)	7.1	11.1	14.7	100.0
RB (%)		156.0	206.6 *

(* p < 0.05 compared with PTX oral control). Data are presented as mean ± S.D. (3–4 rats per group).