Table 1.
Type of treatment and number of enrolled patients/healthy controls in the studies published in the last five years regarding cytokine profiling in BC patients undergoing radiotherapy (RT). See Table 2 for additional details.
| Ref | No. of BC Patients and CTR | Treatment (S, RT, CHT, CRT Combined) | RT TD and d in frs | CHT/HT |
|---|---|---|---|---|
| [27] | 73 | Adj RT | 50 Gy and 2 Gy or 42.56 Gy and 2.66 Gy | No |
| [28] | 209 BC + 106 CTR | S, RT, and CHT | Not mentioned | Not mentioned |
| [29] | 21 oligometastatic BC + 14 healthy donors | SBRT | 30 Gy and 10 Gy | Concomitant CHT/HT and trastuzumab |
| [30] | 73 | S + RT | Not mentioned | No |
| [31] | 534 BC (treated) and 452 CTR | RT (66.7%); RT + CHT (33.3%) | 50–74 Gy and 1.8–2.0 Gy | 1 to 6 cycles of platinum-based CHT |
| [32] | 282 | S and post-operative RT | 40–74 Gy and 1.8–2 Gy | No adjuvant systemic therapy (i.e., CHT or HT) |
| [33] | 149 | Post S treatment including additional CHT, HT, or RT was determined by the individual treating physician | In 128 pts (50 Gy and 2 Gy) | 4 cycles of anthracycline based neo-adj CHT with or without taxane (given before or after the anthracycline) followed by S. Trastuzumab to patients with Her-2 amplified disease |
| [34] | 11 (treated) and 12 CTR | IORT | 20 Gy and 20 Gy | No |
| [35] | 103 | Adj RT | 50 Gy and 2 Gy | 55% of patients received HT |
| [36] | 40 | Not mentioned | Not mentioned | Steroids, CHT, or S |
| [37] | 40 (treated) and 8 CTR | CHT yes/no: 30/18 | 50 Gy (45–76) and 2–2.5 Gy | Bisphosphonate treatment |
| [38] | 26 cases and 44 CTR | S and RT | 50 Gy in 25 frs; 41 Gy in 13 frs or 39 Gy in 13 frs, boost 10 Gy in 4 frs | Tamoxifen yes/no: 61/9 Adj; CHT yes/no: 22/48 |
| [39] | 40 (treated) and 10 healthy donors | RT | 50 Gy in 25 frs; 50 Gy in 25 frs + boost of 10 Gy in 4 frs | No |
| [40] | 51 (treated) and 54 CTR | S + adj RT | 50 Gy and 2 Gy | No |
| [41] | 38 | Intracavitary brachytherapy accelerated hypofractionated partial breast irradiation (IBAPBI) | 34.0 Gy in 10 frs and 3.4 Gy twice per day (with a minimum of 6 hours between each treatment, for a total of 5 treatment days) | No |
Abbreviations for Table 1: adjuvant (adj); breast cancer (BC); chemotherapy (CHT); combined chemo-radiotherapy (CRT); control (CTR); fractions (frs); Gray (Gy); human epidermal growth factor receptor-2 (Her-2); hormone therapy (HT); intracavitary brachytherapy accelerated hypofractionated partial breast irradiation (IBAPBI); intraoperative radiotherapy (IORT); radiotherapy (RT); surgery (S); stereotactic body radiation therapy (SBRT); total dose (TD). See Abbreviation list for other acronyms.