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The effect of extracellular α-synuclein binding to cellular receptor on neuronal or glial cells. Various proteins may fulfill the role of such receptors, including PrPC, LAG3, neurexin 1α [17], TLR2 [23], mGluR5 [12], Fc gamma receptor IIb [24] (Table 1) and others. Gangliosides in the lipid rafts can also act as receptors for extracellular α-synuclein [25]. A–a cell in the absence of extracellular α-synuclein, B–cellular response on α-synuclein binding.
