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. 2019 Jan 21;20(2):440. doi: 10.3390/ijms20020440

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© 2019 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Structural model of the outward-facing VcINDY. Structure of the inward-facing VcINDY as viewed from the membrane bilayer (left panel). VcINDY is drawn as a ribbon diagram, with its scaffold (residues 18-128, 250-357) and transport (residues 129-249, 358-462) domains colored blue and orange, respectively. Na⁺ ions (green) and succinate are shown as spheres. The structural model of the outward-facing VcINDY (right panel). The orientation and coloring scheme are both the same as in panel A. As the transport domain traverses the membrane, VcINDY alternates between the inward- and outward-facing conformations.