Table 5.
Pharmacokinetic parameters following intraperitoneal (IP) administration of the DTX formulations. Cmax—peak serum concentration; Tmax—time to reach peak serum concentration; t1/2—half-life; AUC—area under the curve; MRT—mean residence time.
| Parameters | Onkotaxel® | FL-NDC-DP | C-FL-NDC-DP |
|---|---|---|---|
| Dose (mg/kg) | 13 | 13 | 13 |
| Cmax (mg/L) | 5.605 ± 1.322 | 19.415 ± 3.457 | 34.138 ± 4.752 |
| Tmax (h) | 0.5 | 2 | 2 |
| t1/2 (h) | 3.067 ± 0.878 | 4.544 ± 1.217 | 9.288 ± 1.977 |
| AUC0→t (mg/L.h) | 13.429 ± 2.478 | 131.802 ± 7.331 | 294.287 ± 11.255 |
| AUC0→∞ (mg/L.h) | 14.300 ± 2.115 | 136.563 ± 5.745 | 335.096 ± 14.427 |
| MRT (h) | 3.5 | 6.1 | 10.4 |
The data are expressed as means ± SD, n = 3.