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. 2018 Dec 20;9(1):1. doi: 10.3390/biom9010001

Figure 1.

Figure 1

Proposed models for Kinesin-8 MT) depolymerization: (A) The active depolymerization model proposes that the Kinesin-8 motor protein walks on the MT lattice towards the plus end where it dwells for some time before depolymerizing the MT. (B) The capping model proposes that the Kinesin-8 protein, particularly human Kif18A, suppresses MT dynamics at the plus ends by serving as a capping factor. Capping blocks both growth and shrinkage, ultimately leading to MT catastrophe and depolymerization of the MT lattice.