Table 2.
Biophysical Properties of Kinesin-8 Proteins.
| Kip3 | Klp5/6 | Kif18A | hsKif18B | mKif19A | Klp67A | |
|---|---|---|---|---|---|---|
| Velocity (µm min−1) | 3 [31] 0.71 ± 0.23 [33] 3.2 ± 0.3 [72] |
2.3 ± 0.2 [73] Klp5: 0.4 ± 0.22 * Klp6: 5.22 ± 1.08 * [74] |
11.9 ± 2.3 [68] 18.6 ± 5.4 [70] |
3.12 ± 0.18 [71] 20.9 ± 0.4 [45] |
1.3 ± 0.18 [37] | 3 ± 1.2 [75] |
| Run Length (µm) | 12.4 ± 2.3 [31] 11 ± 2 [72] |
7.2 ± 5.9 [73] | 9.4 ± 5.7 [68] 10.1 ± 4.6 [70] |
0.74 ± 0.22 [71] >7 [45] |
N.D. | N.D. |
| End Dwell Time (s) | 36 ± 4 [72] 38.2 ± 6 [76] |
Klp6: 42 ± 24* [74] | ~55 [69] | 1.42 ± 0.57 [71] 22.8 [45] |
N.D. | N.D. |
| Depolymerization Rate (µm min−1) | ≤2 [31] 0.06 [33] 2.5–4 [72] |
N.S. [73,74] | 0.052 ± 0.026 ** [77] N.S. [78] 0.21 ± 0.08–1.25 ± 0.14 [32] |
N.S. [45] | 1.07 ± 0.23 [37] | N.D. |
Velocities represent single molecule velocities, except for those in italics, which were obtained via gliding assays. Values are for full length constructs unless otherwise noted. * Represents tailless homodimers. ** Represents motor domain and neck linker constructs. Not significant (N.S.). Not determined (N.D.). Some values were converted from their original units for ease of comparison.