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Triptolide inhibits NLRP3-TGFβ1-Smad signaling in the fibrotic ventricle of mice. Experiments were performed as presented in Figure 1. (A–C) IHC for NLRP3, TGF-β1 and p-Smad2/3; bar = 50 μm. (D–F) Fibrosis score. * p < 0.01 vs. control; # p < 0.01 vs. Iso.
