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. 2018 Dec 22;9(1):11. doi: 10.3390/nano9010011

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Detection of precipitated P-6 silica nanoparticles in NR8383 cells by transmission electron microscopy (TEM). Cells were treated with 67.5 µg P-6 per mL in serum-free F-12K and fixed after 90 min (a,b) and 16 h (c–e). (a) P-6 NP attached to the cell; the underlying cell membrane appears undamaged. (b) Early stage of phagosome formation (upper left). (c) A P-6-filled phagolysosome released from a deteriorated cell. (d) NR8383 macrophage filled with numerous P-6-laden phagosomes. (e) Energy dispersive X-ray analysis (TEM-EDX) of a P-6-containing phagosome; white circle (inset) marks the analyzed area; results from black circle were highly similar (not shown). Prominent signals (in arbitrary units) were obtained for silicon (Si) and oxygen (O) at typical positions (in keV) of the spectrum.