Figure 8.

In vitro response of NR8383 alveolar macrophages to silica gel G-3. Particles were dispersed with either 18 J/mL (green) or 270 J/mL (red). (a) lactate dehydrogenase activity (LDH), (b) glucuronidase activity (GLU), (c) H₂O₂ concentration, and (d) tumor necrosis factor alpha (TNF). (e) NR8383 cells after 16 h exposure to P-5, dispersed with 18 J/mL or 270 J/mL; right panels show particles settled onto the bottom of culture well under cell-free conditions. Numerous particles are visible under cell-free conditions and appear similar sized at 18 or 270 J/mL.