Table 1.
Panel of significantly altered metabolites 2 days after dosing with palbociclib (n = 4), fulvestrant (n = 4) or a combination dose of both palbociclib and fulvestrant (n = 4) when comparing dosed groups to control. Values are log transformed fold changes after quantification by multiple reaction monitoring, unpaired two-tailed t-test.
| Metabolite Name | Palbociclib | Fulvestrant | Combination | |||
|---|---|---|---|---|---|---|
| Fold Change | p-Value | Fold Change | p-Value | Fold Change | p-Value | |
| Succinate | 1.6 | 0.0025 | 1.8 | 0.0441 | 1.9 | 0.0021 |
| Malate | −4.0 | 0.0170 | −3.5 | 0.0381 | −34.0 | 0.0002 |
| Fumarate | −2.1 | 0.0189 | −2.1 | 0.0438 | −2.0 | 0.0003 |
| Phosphoenolpyruvate | 1.1 | 0.0450 | N.S | N.S | 1.2 | 0.0014 |
| 6-phosphogluconate | N.S | N.S | −3.7 | 0.0255 | −2.5 | 0.0496 |
| Sedoheptulose-7-phosphate | N.S | N.S | −3.6 | 0.0335 | −3.7 | 0.0003 |
| Serine | N.S | N.S | 1.7 | <0.0001 | N.S | N.S |
| Cholesterol sulfate | N.S | N.S | −5.2 | 0.0332 | N.S | N.S |
| Taurine | N.S | N.S | −2.1 | 0.0380 | N.S | N.S |
| Inosine monophosphate | N.S | N.S | N.S | N.S | −16.1 | 0.0052 |
| Fructose-1-phosphate | N.S | N.S | N.S | N.S | −2.8 | 0.0172 |