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. 2019 Jan 16;24(2):314. doi: 10.3390/molecules24020314

Table 4.

Antimicrobial activity of natural caged xanthones: scortechinones and prenylated.

No. Name/Structure [α]D29(c) a Antimicrobial Activity (MIC)
16N Scortechinone A
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+18° (0.028) S. aureus (128 µg/mL); S aureus SK1 (128 µg/mL); MRSA (128 µg/mL)
17N Scortechinone B
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−105° (0.095) S. aureus (8 µg/mL); S aureus SK1 (2 µg/mL); MRSA (2 µg/mL)
18N Scortechinone C
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−107° (0.014) S. aureus (32 µg/mL); S aureus SK1 (32 µg/mL); MRSA (32 µg/mL)
19N Scortechinone D
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+222° (0.018) S. aureus (>256 µg/mL); S aureus SK1 (>256 µg/mL)
20N Scortechinone E
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−240° (0.025) S. aureus (>256 µg/mL); S aureus SK1 (>256 µg/mL)
21N Scortechinone F
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−333° (0.015) S. aureus (16 µg/mL); S aureus SK1 (4 µg/mL)
22N Scortechinone G
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−95° (0.021) S. aureus (>64 µg/mL); S aureus SK1 (>64 µg/mL)
23N Scortechinone H
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−120° (0.025) S. aureus (>64 µg/mL); S aureus SK1 (4 µg/mL)
24N Scortechinone I
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+43° (0.023) S. aureus (8 µg/mL); S aureus SK1 (8 µg/mL)
25N Scortechinone J
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−200° (0.015) S. aureus (32 µg/mL); S aureus SK1 (8 µg/mL)
26N Scortechinone K
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+48° (0.021) S. aureus (128 µg/mL); S aureus SK1 (128 µg/mL)
27N Scortechinone L
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−176° (0.017) S. aureus (>64 µg/mL); S aureus SK1 (>64 µg/mL)
28N Scortechinone M
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−353° (0.017) S. aureus (32 µg/mL); S aureus SK1 (32 µg/mL)
29N Scortechinone N
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−263° (0.019) S. aureus (32 µg/mL); S aureus SK1 (32 µg/mL)
30N Scortechinone O
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+77° (0.013) S. aureus (>128 µg/mL); S aureus SK1 (>128 µg/mL)
31N Scortechinone P
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+83° (0.012) S. aureus (32 µg/mL); S aureus SK1 (16 µg/mL)
32N 2-isoprenylforbesione
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MRSA USA300 SF8300 (7.20 mm b; >400 µM); MSSA ATCC 25923 (7.56 mm b; 400 µM)
33N Deoxygamboginin
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MRSA USA300 SF8300 (6 mm b); MSSA ATCC 25923 (6 mm b)
34N Hanburin
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MRSA USA300 SF8300 (6 mm b); MSSA ATCC 25923 (6 mm b)
35N Forbesione
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MRSA USA300 SF8300 (7.97 mm b; >400 µM); MSSA ATCC 25923 (7.86 mm b, 200 µM)
36N Dihydroisomorellin
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MRSA USA300 SF8300 (6 mm b); MSSA ATCC 25923 (6 mm b)

MIC: Minimum inhibitory concentration; MRSA: Methicillin-resistant S. aureus; MSSA: Methicillin-sensitive S. aureus; a Specific rotation measured in methanol; b The antimicrobial studies were determined using the disc diffusion method, where the inhibitory growth zones inhibition caused by the tested compounds is expressed in millimeters.