Table 4.
Antimicrobial activity of natural caged xanthones: scortechinones and prenylated.
No. | Name/Structure | a | Antimicrobial Activity (MIC) |
---|---|---|---|
16N | Scortechinone A![]() |
+18° (0.028) | S. aureus (128 µg/mL); S aureus SK1 (128 µg/mL); MRSA (128 µg/mL) |
17N | Scortechinone B![]() |
−105° (0.095) | S. aureus (8 µg/mL); S aureus SK1 (2 µg/mL); MRSA (2 µg/mL) |
18N | Scortechinone C![]() |
−107° (0.014) | S. aureus (32 µg/mL); S aureus SK1 (32 µg/mL); MRSA (32 µg/mL) |
19N | Scortechinone D![]() |
+222° (0.018) | S. aureus (>256 µg/mL); S aureus SK1 (>256 µg/mL) |
20N | Scortechinone E![]() |
−240° (0.025) | S. aureus (>256 µg/mL); S aureus SK1 (>256 µg/mL) |
21N | Scortechinone F![]() |
−333° (0.015) | S. aureus (16 µg/mL); S aureus SK1 (4 µg/mL) |
22N | Scortechinone G![]() |
−95° (0.021) | S. aureus (>64 µg/mL); S aureus SK1 (>64 µg/mL) |
23N | Scortechinone H![]() |
−120° (0.025) | S. aureus (>64 µg/mL); S aureus SK1 (4 µg/mL) |
24N | Scortechinone I![]() |
+43° (0.023) | S. aureus (8 µg/mL); S aureus SK1 (8 µg/mL) |
25N | Scortechinone J![]() |
−200° (0.015) | S. aureus (32 µg/mL); S aureus SK1 (8 µg/mL) |
26N | Scortechinone K![]() |
+48° (0.021) | S. aureus (128 µg/mL); S aureus SK1 (128 µg/mL) |
27N | Scortechinone L![]() |
−176° (0.017) | S. aureus (>64 µg/mL); S aureus SK1 (>64 µg/mL) |
28N | Scortechinone M![]() |
−353° (0.017) | S. aureus (32 µg/mL); S aureus SK1 (32 µg/mL) |
29N | Scortechinone N![]() |
−263° (0.019) | S. aureus (32 µg/mL); S aureus SK1 (32 µg/mL) |
30N | Scortechinone O![]() |
+77° (0.013) | S. aureus (>128 µg/mL); S aureus SK1 (>128 µg/mL) |
31N | Scortechinone P![]() |
+83° (0.012) | S. aureus (32 µg/mL); S aureus SK1 (16 µg/mL) |
32N | 2-isoprenylforbesione![]() |
MRSA USA300 SF8300 (7.20 mm b; >400 µM); MSSA ATCC 25923 (7.56 mm b; 400 µM) | |
33N | Deoxygamboginin![]() |
MRSA USA300 SF8300 (6 mm b); MSSA ATCC 25923 (6 mm b) | |
34N | Hanburin![]() |
MRSA USA300 SF8300 (6 mm b); MSSA ATCC 25923 (6 mm b) | |
35N | Forbesione![]() |
MRSA USA300 SF8300 (7.97 mm b; >400 µM); MSSA ATCC 25923 (7.86 mm b, 200 µM) | |
36N | Dihydroisomorellin![]() |
MRSA USA300 SF8300 (6 mm b); MSSA ATCC 25923 (6 mm b) |
MIC: Minimum inhibitory concentration; MRSA: Methicillin-resistant S. aureus; MSSA: Methicillin-sensitive S. aureus; a Specific rotation measured in methanol; b The antimicrobial studies were determined using the disc diffusion method, where the inhibitory growth zones inhibition caused by the tested compounds is expressed in millimeters.