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. 2019 Jan 16;24(2):314. doi: 10.3390/molecules24020314

Table 11.

Anti-bacterial activity of xanthone derivatives with 2-hydro-3-amino and piperazine groups.

graphic file with name molecules-24-00314-i097.jpg

No. Structure Inhibitory Growth Zones [mm] a
Other Strains Clarithromycin Resistant H. Pylori Strains Metronidazole Resistant H. Pylori Strains Double Resistant H. Pylori Strains
45S R1=R3=H; R2=Me
Inline graphic 		S. aureaus ATCC 25923-13; MRSA 14.002-23; E. coli ATCC 25922-8 ATCC 700684-36
HP 132/194-40
HP 115/168-40		 ATCC 43504-42
HP 125/180-40
HP 139/202-44
HP 143/207-44		 HP 126/181-40
HP 106/154-39
46S R1=R3=H; R2=Me
Inline graphic 		S. aureaus ATCC 25923-11; MRSA 14.002-18 ATCC 700684-32
HP 132/194-34
HP 115/168-26		 ATCC 43504-35
HP 125/180-36
HP 139/202-46
HP 143/207-29		 HP 126/181-40
HP 106/154-33
47S R1=R3=H; R2=Me
Inline graphic 		S. aureaus ATCC 25923-15; MRSA 14.002-23; E. coli ATCC 25922-10 ATCC 700684-34
HP 132/194-42
HP 115/168-46		 ATCC 43504-54
HP 125/180-46
HP 139/202-52
HP 143/207-58		 HP 126/181-50
HP 106/154-47
48S R1=R2=R3=H
Inline graphic 		ATCC 700684-28
HP 132/194-30
HP 115/168-30		 ATCC 43504-21
HP 125/180-28
HP 139/202-38
HP 143/207-36		 HP 126/181-28
HP 106/154-26
49S R1=R2=R4=H
Inline graphic 		S. aureaus ATCC 25923-12; MRSA 14.002-15; E. coli ATCC 2592-9 ATCC 700684-35
HP 132/194-42
HP 115/168-38		 ATCC 43504-41
HP 125/180-36
HP 139/202-48
HP 143/207-42		 HP 126/181-48
HP 106/154-39
50S R1=R2=R4=H
Inline graphic 		ATCC 700684-24
HP 132/194-22
HP 115/168-17		 ATCC 43504-11
HP 125/180-17
HP 139/202-26
HP 143/207-22		 HP 126/181-23
HP 106/154-16
51S R1=R2=R4=H
Inline graphic 		S. aureaus ATCC 25923-12; MRSA 14.002-11 ATCC 700684-34
HP 132/194-32
HP 115/168-31		 ATCC 43504-36
HP 125/180-40
HP 139/202-40
HP 143/207-32		 HP 126/181-34
HP 106/154-31
52S R1=R2=R4=H
Inline graphic 		ATCC 700684-20
HP 132/194-16
HP 115/168-25		 ATCC 43504-19
HP 125/180-20
HP 139/202-20
HP 143/207-22		 HP 126/181-20
HP 106/154-21
53S R1=R2=R4=H
Inline graphic 		ATCC 700684-27
HP 132/194-29
HP 115/168-34		 ATCC 43504-28
HP 125/180-32
HP 139/202-38
HP 143/207-32		 HP 126/181-38
HP 106/154-31
54S R1=R2=R4=H
Inline graphic 		ATCC 700684-25
HP 132/194-30
HP 115/168-33		 ATCC 43504-23
HP 125/180-35
HP 139/202-32
HP 143/207-36		 HP 126/181-36
HP 106/154-34
55S R1=R2=R4=H
Inline graphic 		S. aureaus ATCC 25923-9; MRSA 14.002-11 ATCC 700684-38
HP 132/194-48
HP 115/168-44		 ATCC 43504-39
HP 125/180-50
HP 139/202-54
HP 143/207-50		 HP 126/181-56
HP 106/154-45
56S R1=Cl; R2=R4=H
Inline graphic 		S. aureaus ATCC 25923-10; MRSA 14.002-16 ATCC 700684-34
HP 132/194-40
HP 115/168-40		 ATCC 43504-37
HP 125/180-40
HP 139/202-40
HP 143/207-48		 HP 126/181-45
HP 106/154-40
57S R1=Cl; R2=R4=H
Inline graphic 		S. aureaus ATCC 25923-12; MRSA 14.002-13 ATCC 700684-26
HP 132/194-22
HP 115/168-25		 ATCC 43504-25
HP 125/180-32
HP 139/202-28
HP 143/207-23		 HP 126/181-25
HP 106/154 -21
58S R1=Cl; R2=R4=H
Inline graphic 		S. aureaus ATCC 25923-16; MRSA 14.002-16; E. coli ATCC 25922-9 ATCC 700684-35
HP 132/194-44
HP 115/168-46		 ATCC 43504-50
HP 125/180-42
HP 139/202-40
HP 143/207-50		 HP 126/181-26
HP 106/154-30
59S R1=Cl; R2=R4=H
Inline graphic 		S. aureaus ATCC 25923-17; MRSA 14.002-15; E. coli ATCC 25922-9 ATCC 700684-34
HP 132/194-36
HP 115/168-38		 ATCC 43504-28
HP 125/180-32
HP 139/202-32
HP 143/207-33		 HP 126/181-41
HP 106/154-35
60S R1=Cl; R2=R4=H
Inline graphic 		S.aureaus ATCC 25923-12; MRSA 14.002-15 ATCC 700684-23
HP 132/194-19
HP 115/168-24		 ATCC 43504-15
HP 125/180-18
HP 139/202-31
HP 143/207-26		 HP 126/181-20
HP 106/154-19
61S R1=Cl; R2=R4=H
Inline graphic 		S. aureaus ATCC 259-16; MRSA 14.002-16 ATCC 700684-30
HP 132/194-32
HP 115/168-28		 ATCC 43504-24
HP 125/180-28
HP 139/202-36
HP 143/207-40		 HP 126/181-26
HP 106/154-26
62S R1=Cl; R2=R4=H
Inline graphic 		ATCC 700684-22
HP 132/194-24
HP 115/168-27		 ATCC 43504-24
HP 125/180-27
HP 139/202-26
HP 143/207-24		 HP 126/181-25
HP 106/154-24
63S R1=Cl; R2=R4=H
Inline graphic 		S. aureaus ATCC 25923-9; MRSA 14.002-9 ATCC 700684-19
HP 132/194-22
HP 115/168-25		 ATCC 43504-22
HP 125/180-29
HP 139/202-30
HP 143/207-25		 HP 126/181-27
HP 106/154-25

a The antimicrobial studies were determined using a disc diffusion method, where values correspond to the means of the zones of growth inhibition caused by the tested compounds in 1% concentration in millimeters [110]; * Stereogenic center.