Table 13.
Antimicrobial activity of xanthone derivatives of C-2-substituted.
| No. | Structure | Antimicrobial Activity (Inhibitory Growth Zones or MIC) |
|---|---|---|
| 76S | R1=H
|
aC. lusitaniae (8 mm); T. mentagrophytes (18 mm); S. aureus (9 mm); E.faecalis (9 mm) |
| 77S | R1=Cl
|
aT. mentagrophytes (12 mm) |
| 78S | R1=H
|
M. tuberculosis H37Rv (>2.5% with 35% inhibition) |
| 79S | R1=H
|
M. tuberculosis H37Rv (>2.5% with 32% inhibition) |
| 80S | R1=H
|
M. tuberculosis H37Rv (>2.5% with 35% inhibition) |
| 81S | R1=H
|
M. tuberculosis H37Rv (>2.5% with 34% inhibition) |
| 82S | R1=H
|
M. tuberculosis H37Rv (>2.5% with 63% inhibition) |
| 83S | R1=H
|
M. tuberculosis H37Rv (>2.5% with 3% inhibition) |
| 84S | R1=H
|
M. tuberculosis H37Rv (>2.5% with 25% inhibition) |
| 85S | R1=H
|
M. tuberculosis H37Rv (>2.5% with 14% inhibition) |
| 86S | R1=H
|
M. tuberculosis H37Rv (<2.5% with 94% inhibition) |
| 87S | R1=H
|
M. tuberculosis H37Rv (>2.5% with 24% inhibition) |
| 88S | R1=H
|
M. tuberculosis H37Rv (>2.5% with 59% inhibition) |
MIC: Minimum inhibitory concentration; a The antimicrobial studies were determined using a disc diffusion method, where the inhibitory growth zones showed inhibition at 1% concentration against representative strains of microorganisms C. albicans, C. glabrata, C. krusei, C. lusitaniae, C. neoformans, A. fumigatus, T. mentagrophytes, S. aureus, E. faecalis, E. coli, K. pneumonia, and P. aeruginosa; only the strains with activity were expressed; * Stereogenic center.