FTIR spectra confirming the introduction of cysteinyl-β-CD, EDA-β-CD, and DOX on SiO2@Ag NPs. (a) Immobilized cysteinyl-β-CD (N–H bending vibration at 1627 cm−1, CH2 bending vibration at 1424 cm−1, red) on the SiO2@Ag NPs and DOX (ketone group stretching at 1718 cm−1, C=C stretching vibration at 1608 cm−1 and 1574 cm−1, and methyl group bending at 1403 cm−1, blue) on SiO2@Ag@cysteinyl-β-CD NPs. (b) Immobilized EDA-β-CD (N–H bending vibration at 1635 cm−1, CH2 bending vibration at 1424 cm−1, red) on SiO2@Ag NPs and DOX (ketone group stretching at 1724 cm−1, C=C stretching vibration at 1611 cm−1 and 1575 cm−1, methyl group bending at 1409 cm−1, blue) on SiO2@Ag@EDA-β-CD NPs. (i) SiO2@Ag NPs, (ii) SiO2@Ag@cysteinyl-β-CD NPs and SiO2@Ag@EDA-β-CD NPs, (iii) NPs after loading DOX onto SiO2@Ag@cysteinyl-β-CD NPs and SiO2@Ag@EDA-β-CD NPs.