Table 1.

Supramolecular systems decorated with homing peptides able to selectively recognize integrin receptors or membrane receptors belonging to the GPCR superfamily. The bioactive peptide, the peptide conjugation, the encapsulated API, and the corresponding references are reported.

Receptor	Peptide Sequence	Peptide Derivative	Drug	Ref.
Integrin receptor Avβ3	c(RGDfK)	c(RGDfK)-NHS-PEG-PLA	CA4	[99]
	c(RGDfK)	c(RGDfK)-SH post liposome modification	CDDP	[100]
	c(RGDfC)	MBPE-c(RGDfC) post-insertion	DOX	[101]
	c(RGDf[N-Met]K)	c(RGDf[N-Met]K(Ac-SCH2CO))	DOX	[102]
	c(RGDyK)	DSPE-PEG- c(RGDyK)	CDDP	[103]
	cAbaRGD cAmpRGD	DSPE-PEG-cAbaRGD DSPE-PEG- cAmpRGD	DOX DOX	[104]
	iRGD	iRGD-HES-SS-C18 NCs	DOX/sorafenib	[105]
G-Protein coupled receptor	Octreotide	OCA-DOTA/ OCA-DTPAGlu	Gd-complex	[106]
	Octreotide	(C18)2(AdOO)5OCT	Gd-complex	[107]
	Octreotide	(C18)2(AdOO)5OCT	CDDP/DOX	[108]
	Octreotide	OCT-(PTX)-PEG-b-PCL	PTX	[109]
	Octreotide	Oct-Phe-PEG-SA	DOX	[110]
	Octreotide	H40-PLA-PEG-OCT	TDP-A	[111]
	Octreotide	SAMA-TOC post liposome modification	111In-DTPA	[112]
	Octreotide	HSPE-PEG4000-OCT	DOX	[113]
	[Tyr3]-Octreotate	Maleimido-TATE	64Cu-DOTA	[114]
	KE108	KE108 post micelle modification via NHS	TDP-A AB3	[115] [116]
	[7–14]BN wild-type	(C18)2-L5-[7–14]BN (C18)2-PEG3000-[7–14]BN	111In-DOTA	[117]
	[7–14]BN-AA1 analogue	MonY-BN-AA1	DOX AUL12 DOX	[118] [119] [120]
	CCK8	(C18)2-L5CCK8	Gd-DOTA/Gd-DTPA	[121]