Table 1.

Effect of Jobelyn, Diazepam, and Pyridoxine on Isoniazid-induced seizure episodes in mice

Treatment	Onset of Seizure (Min)	Seizure (%)	Latency to Death (Min)	Death (%)
Control	48.67±1.687	100	53.83±1.302	100
JB (10 mg/kg)	48.17±1.493	100	51.50±3.085	100
JB (25 mg/kg)	52.67±3.518	100	58.50±3.008	100
JB (50 mg/kg)	62.33±3.870*	100	62.50±4.552	100
DZ (5 mg/kg)	85.17±2.072*	70	88.83±10.95*	70
Pyridoxine (300 mg/kg)	35.83±2.496*	100	35.67±2.565	100

Values are expressed as Mean±SEM for 5 animals per group.

^*P<0.05 compared with controls (ANOVA followed by the Newman-Keuls test).

Abbreviations: JB: Jobelyn; DZ: Diazepam