Fig. 5.

Hsa_circ_0081143 regulated GC progression by modulating miR-646/CDK6 axis. a Hsa_circ_0081143 expression was positively correlated with CDK6 expression in GC tissues. b, c Hsa_circ_0081143 suppression decreased CDK6 expression both in mRNA (b) and protein (c) levels, while miR-646 inhibitors reversed it. d CCK-8 assay showed that hsa_circ_0081143 inhibition reduced GC cells proliferation which could be reversed by CDK6 overexpression. e Transwell assay showed that hsa_circ_0081143 inhibition reduced GC cells invasion ability which could be abolished by CDK6 upregulation. f The sensitivity of si-circ_004451 transfected GC cells to cisplatin could be reversed by CDK6 overexpression. *P < 0.05