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Trends of susceptibility to each antibiotic agent in the early (2007–2011) and late (2012–2016) periods of the study. Non-susceptibility to imipenem, piperacillin-tazobactam, cefepime, and trimethoprim-sulfamethoxazole increased in both ICU and non-ICU settings, while non-susceptibility to ciprofloxacin and ceftazidime increased in non-ICU settings but remained high in ICU settings. *p < 0.05, **p < 0.01, ***p < 0.005, ****p < 0.0001
