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. 2019 Feb 1;20:102. doi: 10.1186/s12864-018-5387-1

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© The Author(s) 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License(http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Evolutionary conservation of the CpG TL compared to the background CpG sites (BG). a Conservation in mammals and b in primates, c repeats determined by RepeatMasker, d Eigen non-coding functionality score. Whiskers (abc) represent standard deviation out of the 50 random background samples. Fisher exact test, p-value <5E−4 (a - c), Kolmogorov-Smirnov statistic for 2 samples p-value <5E−4 (d)