Fig. 3.

CpG TL in regulatory regions. Over-representation of CpG TL in a open chromatin regions (DNaseI), b transcription start sites determined by CAGE, c enhancers determined by histone modifications, d enhancers determined by FANTOM5. No difference between CpG TL and CpG BG counts in e CpG islands while f CpG TL are over-represented in CpG islands shores. Panel g represents averaged across 127 cell types ratio of TL / BG in chromatin states determined by chromHMM. The color g reflects absolute number of the CpG TL located in a given chromatin state. Whiskers (a-f) represent standard deviation of the 50 random background samples. Fisher exact test, p-value <5E−4