Table III.

Summary of the Independent Mutations in the Liver cII Gene of Big Blue Mice Treated With AFB₁ as Neonates and Adults

	AFB1-treateda				Controlb
	Neonatal		Adult		Neonatal		Adult
Type of mutation	Number	%	Number	%	Number	%	Number	%
G:C → C:G	5	7	1	2	3	5	3	9
G:C → A:T	6	9	18	32	28	50	13	41
G:C → T:A	53	76	28	51	12	21	2	6
A:T → T:A	1	1	2	4	0	0	0	0
A:T → C:G	0	0	0	0	5	9	3	9
A:T → G:C	0	0	0	0	1	2	3	9
Frameshift	3	4	4	7	7	13	8	25
Tandem	2	3	2	4	0	0	0	0
Total mutants screened	70	100	55	100	56	100	32	100

^aThe mutational spectra for AFB₁-treated neonatal and adult mice were significantly different from their respective concurrent controls (P < 0.0001). Also, there was a significant difference between the AFB₁-treated neonatal and adult mice (P < 0.01). There was no significant difference between the two control groups.

^bData for controls were obtained from our previous study [Chen et al., 2005]. The control animals were treated with DMSO at 2 μl/g body weight.