Table 1.
Demographic, cognitive factor and PRSs
| Control | Siblings | Schizophrenia | Schizophrenia and Control group | Sibling and Control group | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| n | 607 | 290 | 416 | - | - | ||||||
| Male, n | 285 | 122 | 316 | - | - | ||||||
| Age, mean (SD) | 31.05 (9.78) | 35.58* (9.64) | 34.38* (9.89) | - | - | ||||||
| n | Mean | SD | n | Mean | SD | n | Mean | SD | P-value | P-value | |
| PRS | 607 | 0 | 1 | 286 | 0.31 | 0.94 | 416 | 0.78 | 1.05 | 4.10 × 10−31 | 1.37 × 10−5 |
| Verbal memory (F1) | 598 | 0 | 1 | 284 | −0.38 | 1.08 | 415 | −2.00 | 1.33 | 7.97 × 10−114 | 4.97 × 10−7 |
| n-back (F2) | 561 | 0 | 1 | 216 | −0.57 | 1.31 | 282 | −1.82 | 1.53 | 4.38 × 10−62 | 8.51 × 10−9 |
| Visual memory (F3) | 345 | 0 | 1 | 280 | −0.10 | 1.36 | 405 | −1.92 | 2.32 | 3.96 × 10−45 | 0.33 |
| Processing speed (F4) | 603 | 0 | 1 | 283 | −0.53 | 1.06 | 416 | −1.98 | 1.1 | 2.36 × 10−137 | 1.20 × 10−12 |
| Card sorting (F5) | 583 | 0 | 1 | 279 | −0.47 | 1.24 | 391 | −1.80 | 1.65 | 8.14 × 10−71 | 3.16 × 10−8 |
| Span (F6) | 523 | 0 | 1 | 286 | −0.27* | 1.04 | 414 | −1.15*,^ | 1.13 | 3.95 × 10−54 | 2.71 × 10−4 |
| g | 594 | 0 | 1 | 277 | −0.60* | 1.16 | 412 | −2.96*,^ | 1.72 | 3.90 × 10−151 | 2.86 × 10−13 |
PRS = PRS with P-value cut-off at 0.05. Data on PRS and cognitive variables have been standardized according to the mean and standard deviation of the control group. *Indicates P < −0.001 when compared to controls; ^indicates P < 0.001 when compared to siblings.