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mGluR5 activation induces Cx43-pS368 via PKC. (A-B) Two-hour treatment with CHPG, mGluR5 agonist, and BIM, PKC inhibitor, do not alter Cx43 expression (n = 10). (C) Two-hour treatments with CHPG dose-dependently raises Cx43-pS368 expression (n = 9–12). (D) About 50 and 100 μM CHPG increases Cx43-pS368 expression, which is blocked by PKC inhibition (1 μM BIM) (n = 8–10), suggesting that mGluR5 activation raises Cx43-pS368 via PKC
