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Hcy impairs EC wound repair via mGluR5. Hcy (20 μM) significantly reduces EC (A) daily repair distance and (B) repair rate for one to six days, which are rescued by treatment with the mGluR5-selective antagonist MPEP (25 μM) (n = 3). CHPG, a mGluR5-specific agonist, dose-dependently impairs (C) EC repair distance within each day (n = 3) and (D) EC repair rate for one- to six- day observations (n = 3).
